CGF therapy

CGF is obtained through a 4-step centrifugation process (Medifuge Silfradent) with variable speeds. This yields a platelet concentration 5–8? higher than baseline (PRP achieves only 2–3?) plus a dense fibrin matrix that releases growth factors slowly over 7–14 days (PRP releases over 3–5 days). Clinical efficacy is 3–4? greater.

PDGF (platelet-derived growth factor) — cell migration and proliferation; TGF-?1 — collagen and matrix synthesis; VEGF — angiogenesis (new vessels); IGF-1 — cell proliferation and anabolism; EGF — epithelialisation; BMP-2/7 — bone regeneration. All in physiological, not pharmacological concentrations — therefore without side effects.

It depends on the diagnosis. Mild tendinopathy — 1 procedure. Moderate stage II osteoarthritis — 1–2 procedures spaced 4–8 weeks apart. Severe stage III osteoarthritis or FBSS — 2–3 procedures in a sequence. The decision is based on the dynamics of clinical and MRI findings. A maintenance procedure is usually performed after 12–24 months.

Blood draw (15–60 ml depending on the treatment area) — 5 minutes. 4-step centrifugation — 12 minutes. Site preparation and local anaesthesia — 5 minutes. Ultrasound-guided injection — 10–20 minutes. Post-procedure observation — 30 minutes. Total: 60–90 minutes on an outpatient basis.

First wave — pain reduction by 30–50% within 2–4 weeks (anti-inflammatory effect of CGF). A temporary plateau may occur at 6–8 weeks. Second wave — by week 12 with true tissue regeneration (visible on MRI). Maximum effect at 3–6 months. In 70% of patients, slow improvement continues for 12–18 months.

Yes. Since the patient’s own blood is used, there is no risk of allergy, rejection or immune conflict. It is safe in rheumatoid arthritis (basic therapy is continued), compensated diabetes mellitus, and cardiovascular disease. Relative contraindications: thrombocytopenia <100?10?/L, active infection, oncological disease in the active phase.

Yes — this is the MIBRAR® standard. CGF + Lipogems® for deep cartilage damage. CGF + BMAC for bone necrosis. CGF + shockwave therapy for chronic tendinopathies. CGF cannot be combined with corticosteroid injection in the same area (steroids must be discontinued at least 6 weeks beforehand).

Stop NSAIDs 7 days beforehand (ibuprofen, diclofenac, meloxicam, aspirin in doses >100 mg). Anticoagulants — by agreement with the cardiologist. 24 hours before — avoid alcohol and intense physical activity. On the day of the procedure — a light breakfast and plenty of fluids (2 L of water). The full checklist is on the preparation page.