What happens with osteoporosis

Bone tissue is constantly renewed: osteoclasts break down old bone, osteoblasts build new bone. With osteoporosis, the balance is disrupted — destruction exceeds restoration. The bone becomes porous and fragile.

Risk Factors

Non-modifiable

Female sex (estrogens protect bone). Age over 50 years. Menopause (loss of up to 5% bone mass per year in the first 5 years). Family history of fractures. Caucasian or Asian race. Low weight/asthenic build.

Modifiable

Vitamin D and calcium deficiency. Sedentary lifestyle. Smoking (-10% bone mass). Alcohol abuse (> 3 servings per day). Low BMI (< 19).

Secondary Osteoporosis

Glucocorticoids (> 5 mg prednisolone > 3 months — the most common cause). Hyperthyroidism. Hyperparathyroidism. Testosterone deficiency. Celiac disease (malabsorption). Rheumatoid Arthritis. Type 1 Diabetes Mellitus.

Typical osteoporotic fractures

Vertebral Compression Fractures (46%)

The most common. Often asymptomatic (incidental finding on X-ray). Height loss, kyphosis («widow's hump»). May cause chronic back pain. Each fracture increases the risk of the next by 5 times.

Femoral Neck Fracture (16%)

The most dangerous: 20% mortality in the first year. 50% of patients do not return to previous activity level. Requires surgical treatment. Average age: 80 years.

Distal Radius Fracture (16%)

«Colles' fracture» — from falling on outstretched hand. First «warning sign» of osteoporosis, often at 55-65 years. Densitometry is mandatory after this fracture.

Proximal Humerus Fracture

From falling on shoulder. Especially common in women over 70 years. Complex treatment, prolonged rehabilitation.

Diagnosis

DEXA (Densitometry)

Gold standard. Dual-energy X-ray absorptiometry of lumbar spine and femoral neck. T-score: normal > -1.0, osteopenia -1.0 to -2.5, osteoporosis < -2.5. Indicated: all women > 65 years, men > 70 years, earlier with risk factors.

FRAX

10-year fracture risk calculator (WHO). Considers: age, sex, BMI, previous fractures, family history, smoking, alcohol, glucocorticoids, RA, secondary osteoporosis, BMD. Helps decide on treatment necessity.

Laboratory Tests

Calcium, phosphorus, vitamin D (25-OH), PTH, TSH, testosterone (in men). Bone turnover markers: CTX (resorption), P1NP (formation). Exclusion of secondary causes.

Spine X-ray

Lateral views Th4-L4 to detect compression fractures. VFA (Vertebral Fracture Assessment) on DEXA machine — screening for fractures with minimal radiation dose.

Role of MIBRAR® in osteoporosis

Important: MIBRAR® does not replace anti-osteoporosis therapy (bisphosphonates, denosumab, teriparatide). MIBRAR® addresses orthopedic problems that develop in the context of osteoporosis.

1. Joint Regeneration

Osteoporosis accelerates the development of osteoarthritis: subchondral bone loses strength, cartilage experiences uneven loading. MIBRAR® regenerates cartilage and strengthens subchondral bone (stem cells stimulate osteoblasts).

2. Healing of Microfractures

Osteoporotic bone is prone to microfractures (trabecular microcracks, stress reactions). CGF plus stem cells accelerate consolidation and prevent progression to complete fracture.

3. Recovery After Fractures

Following surgical treatment of osteoporotic fractures, MIBRAR® accelerates bone healing and recovery of surrounding soft tissues (ligaments, tendons, muscles).

4. Spine Treatment

Compression fractures of vertebrae with chronic pain. MIBRAR® restores damaged discs and facet joints, reduces inflammation, regenerates bone tissue.

87%Improvement in Function

CombinedMIBRAR® + anti-osteoporosis therapy

0Hospitalization

30 minProcedure

Osteoporosis Destroys — MIBRAR® Restores

Comprehensive approach: bone strengthening plus joint regeneration.

Schedule a Consultation

Prevention of Osteoporosis

Vitamin D and Calcium

Vitamin D: 1000-2000 IU/day (target level 25-OH-D > 30 ng/mL). Calcium: 1000-1200 mg/day (preferably from food: dairy products, broccoli, almonds). Vitamin D deficiency affects 70% of the population in northern latitudes.

Physical Activity

Weight-bearing exercise: walking 30 minutes/day, dancing, climbing stairs. Strength training 2-3 times per week. Balance training to prevent falls (tai chi has been shown to reduce risk by 40%).

Lifestyle

Smoking cessation. Limiting alcohol. Maintaining normal weight. Fall prevention: rugs, handrails, lighting, vision correction, medication review (sedatives).

Questions About Osteoporosis

What is osteoporosis?

A systemic skeletal disease: decreased bone mineral density and disrupted microarchitecture. Bones become fragile and break with minimal trauma. It progresses silently until the first fracture occurs.

How does MIBRAR® help with osteoporosis?

MIBRAR® restores joints and tissues damaged in the context of osteoporosis: regenerates cartilage, accelerates healing of microfractures, stimulates osteoblasts. It does not replace anti-osteoporosis therapy.

At what age should bone density screening begin?

Women from age 65 (from menopause if risk factors are present). Men from age 70. With glucocorticoid use, after fracture from minimal trauma — regardless of age.

Can bone density be restored?

Yes. Modern medications (teriparatide, romosozumab) increase BMD by 10-15% over 2 years. Vitamin D plus calcium plus physical activity form the essential foundation. MIBRAR® additionally stimulates osteoblasts locally.